Taylor, P.C., Clark, A.J., Marsh, A., Singer, D.R., Dilly, S.J. (2013). A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins.  Chem. Commun. (Camb.) 49(83): 9588--9590.

FBrf0224712

Research paper

Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.