FB2026_03 , released September 17, 2026
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Citation
Marzluff, W.F., Duronio, R.J. (2014). Genome stress response in early development.  Dev. Cell 29(4): 375--376.
FlyBase ID
FBrf0225225
Publication Type
Note
Abstract
Cells with irreparable genomic damage pose a problem for development and must be eliminated to prevent disease. Reporting in this issue of Developmental Cell, Iampietro et al. (2014) describe a mechanism in Drosophila that removes damaged nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of specific mRNAs within the nucleus.
PubMed ID
24871944
PubMed Central ID
PMC4107455 (PMC) (EuropePMC)
DOI
10.1016/j.devcel.2014.05.010
Related Publication(s)
Research paper

Developmentally regulated elimination of damaged nuclei involves a chk2-dependent mechanism of mRNA nuclear retention.
Iampietro et al., 2014, Dev. Cell 29(4): 468--481 [FBrf0225165]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference