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Citation
Nakajima, Y., Gibson, M.C. (2015). Epithelial cell division: aurora kicks lgl to the cytoplasmic curb.  Curr. Biol. 25(1): R43--R45.
FlyBase ID
FBrf0227308
Publication Type
Note
Abstract
The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.
PubMed ID
25562301
PubMed Central ID
DOI
10.1016/j.cub.2014.11.052
Related Publication(s)
Research paper

Aurora kinases phosphorylate lgl to induce mitotic spindle orientation in Drosophila epithelia.
Bell et al., 2015, Curr. Biol. 25(1): 61--68 [FBrf0227227]

Aurora A Triggers Lgl Cortical Release during Symmetric Division to Control Planar Spindle Orientation.
Carvalho et al., 2015, Curr. Biol. 25(1): 53--60 [FBrf0227229]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference