Montagne, J. (2016). A Wacky Bridge to mTORC1 Dimerization.  Dev. Cell 36(2): 129--130.

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Note

The activity of the mTORC1 protein complex depends on multiple metabolic inputs that regulate dimerization, recruitment to the lysosome, and activation. In this issue of Developmental Cell, David-Morrison et al. (2016) show that the Drosophila protein Wacky and its mammalian counterpart WAC act as adaptors in the process of mTORC1 dimerization.