FB2026_03 , released September 17, 2026
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Citation
Caous, R., Richard-Parpaillon, L., Giet, R. (2016). Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.  Mol. Cell. Oncol. 3(3): e1140261.
FlyBase ID
FBrf0232636
Publication Type
Note
Abstract
Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.
PubMed ID
27314090
PubMed Central ID
PMC4909412 (PMC) (EuropePMC)
DOI
10.1080/23723556.2016.1140261
Related Publication(s)
Research paper

Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.
Caous et al., 2015, Nat. Commun. 6: 8879 [FBrf0230147]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cell. Oncol.
    Title
    Molecular & cellular oncology
    ISBN/ISSN
    2372-3556
    Data From Reference
    Human Disease Models (1)