West, C., Silverman, N. (2017). Drosophilosophical: Re-thinking Adaptive Immunity in the Fly.  Cell 169(2): 188--190.

FBrf0235258

Note

For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes.