Jackson, G.R. (2017). SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins.  Neuron 94(1): 4--5.

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Note

In this issue of Neuron, Ishiguro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31. Using a Drosophila model, the authors demonstrate that TDP-43 and other RNA-binding proteins act as chaperones to regulate the formation of toxic RNA aggregates.