Nave, K.A., Tzvetanova, I.D., Schirmeier, S. (2017). Glial Cell Evolution: The Origins of a Lipid Store.  Cell Metab. 26(5): 701--702.

FBrf0237215

Note

In Drosophila, neuronal mitochondria that lack OXPHOS generate ROS-protective fatty acids and lipid droplets in associated glia. In this issue, Liu et al. (2017) demonstrate that neuronal lipid synthesis is driven by the glial lactate shuttle. This lipoprotein-dependent deposition of lipids may be at the origin of glial specializations evolving in vertebrates.