Abstract
This study aims to assess the safety of a lepidopteran insecticide, Flubendiamide, in a non-target dipteran model insect, Drosophila melanogaster, at tissue/cellular and enzyme/protein levels. Enhanced blue coloration through Trypan blue dye exclusion test suggests greater tissue damage. Furthermore, dose- dependent increase (p < 0.05) in the cytochrome P450 1A1 enzyme activity suggests activation of the Phase-I detoxifying mechanism. Thus, this study confirms Flubendiamide-induced toxic stress in Drosophila that might be replicated in other non-target organisms. Keywords: Cytochrome P450, Drosophila, Flubendiamide, Tissue damage.
