Becker, L.A., Gitler, A.D. (2018). Ataxin-2 Is Droppin' Some Knowledge.  Neuron 98(4): 673--675.

FBrf0239003

Note

Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.