Bazan, N.G., Gordon, W.C. (2019). Learning from the Fly Photoreceptor on How Synapses Integrate Gene Expression to Sustain Retina and Brain Function.  Neuron 101(4): 548--550.

FBrf0241656

Note

Synapse dysfunction is thought to contribute to neurodegenerative diseases. In this issue of Neuron, Tsai et al. (2019) uncover how membrane phospholipid biosynthesis regulates Drosophila photoreceptor (PR) degeneration and the synaptic vesicle pool through a transcriptional-translational feedback loop from the synaptic terminal to the nucleus.

PMC8922300 (PMC) (EuropePMC)