FB2026_02 , released June 18, 2026
Reference Report
Open Close
Reference
Citation
Lechtenberg, B.C., Routh, A. (2018). Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense.  Cell Host Microbe 24(4): 467--469.
FlyBase ID
FBrf0243128
Publication Type
Note
Abstract
Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.
PubMed ID
30308151
PubMed Central ID
DOI
10.1016/j.chom.2018.09.012
Related Publication(s)
Research paper

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.
Nayak et al., 2018, Cell Host Microbe 24(4): 542--557.e9 [FBrf0240293]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Host Microbe
    Title
    Cell Host & Microbe
    Publication Year
    2007--
    ISBN/ISSN
    1931-3128 1934-6069
    Data From Reference