Droujinine, I.A., Perrimon, N. (2019). The Multidimensional Organization of Interorgan Communication Networks.  Dev. Cell 50(4): 395--396.

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Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organization in sex-specific interorgan communication.