FB2026_02 , released June 18, 2026
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Chien, C., Dickman, D. (2021.1.11). Location data for Sol1 mutations. 
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FBrf0248055
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See the associated file for a report on the two Sol1 CRISPR alleles (Sol1bk1 and Sol1bk2) reported in FBrf0246954 Kiragasi et al., 2020.
Sol1bk2 can be characterized as a 5 bp deletion (ATTAA) and 10 bp insertion (CCAAGGTGGT) starting in the codon for amino acid 22 of Sol1-RC.
In Sol1bk1 there is a deletion of a T in the codon for amino acid 23 of Sol1-RC. This leads to an immediate stop codon. The exact nature of the lesion is unclear because the sequence fidelity drops off shortly after and it is difficult to determine when the mutant sequence goes back into alignment with the wild type sequence.
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Research paper

The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.
Kiragasi et al., 2020, Proc. Natl. Acad. Sci. U.S.A. 117(41): 25830--25839 [FBrf0246954]

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File date: 2021.1.11 ; File size: 20159 ; File format: docx ; File name: Dickman.2021.1.11-Sol1_mutations.docx
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    English
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