Bernstein, B.W., Bamburg, J.R. (2010). Neuronal guidance: a redox signal involving Mical.  Curr. Biol. 20(8): R360--R362.

FBrf0250016

Note

Mical, a redox enzyme, binds the cytoplasmic domain of the semaphorin receptor plexin A and mediates semaphorin-signaled collapse of the actin cytoskeleton. Recent work now shows that Mical's ability to bind actin filaments and destabilize them in a NADPH-dependent manner is responsible for semaphorin 1a's effects.