Nettnin, E.A., Sallese, T.R., Nasseri, A., Saurabh, S., Cavanaugh, D.J. (2021). Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms.  iScience 24(9): 103001.

FBrf0251024

Research paper

The circadian system is comprised three components: a network of core clock cells in the brain that keeps time, input pathways that entrain clock cells to the environment, and output pathways that use this information to ensure appropriate timing of physiological and behavioral processes throughout the day. Core clock cells can be divided into molecularly distinct populations that likely make unique functional contributions. Here we clarify the role of the dorsal neuron 1 (DN1) population of clock neurons in the transmission of circadian information by the Drosophila core clock network. Using an intersectional genetic approach that allowed us to selectively and comprehensively target DN1 cells, we show that suppressing DN1 neuronal activity alters the magnitude of daily activity and sleep without affecting overt rhythmicity. This suggests that DN1 cells are dispensable for both the generation of circadian information and the propagation of this information across output circuits.

PMC8413890 (PMC) (EuropePMC)