Carvalho-Santos, Z., Ribeiro, C. (2023). Do flies dream of protein? How the gut regulates sleep depth.  Cell Metab. 35(5): 732--734.

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Note

A recent study by Titos et al. in Cell shows that protein-rich diets are strong modulators of sleep depth in Drosophila and identifies the gut-secreted neuropeptide CCHa1 as the mediator of this effect. In the brain, CCHa1 controls dopamine release from a small set of neurons, thereby modulating arousability by integrating internal state with sensory information.