FB2026_03 , released September 17, 2026
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Johnson, T. (2024.4.25). Details for Hmgcl[Q25] and Hn[I21] mutations. 
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FBrf0259410
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HmgclQ25 was generated using sgRNA-GS00616 from TRiP targeting 5’-GGTTACAAGCGCGGCCAATCAGG-3’ at the start of the second exon. The allele is a deletion of 11bp (CAGGTGCGAAT) including the last 4bp of the guide RNA (CAGG) defined as c.73_83del causing p.Gln25CysfsX41.
HnK27 (designated HnI21 in the paper) was generated using sgRNA-GS00942 from TRiP targeting 5’-AGTCGAGGGTGTAGATATTAAGG-3’ at the start of exon 2 of Hn-RA. The allele is a single base deletion c.78delT (based on Hn-RA isoform) causing p.Lys27ArgfsX33 (Hn-PA). The allele was HnK27 since the original name was due to incorrect annotation of the mutation.
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    English
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    Alleles (2)
    Genes (2)