Ozturan, D., de Boer, C.G. (2024). Silent silencers: Leave no trace.  Mol. Cell 84(23): 4473--4475.

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Note

The regulatory mechanisms of silencers have remained poorly understood. In this issue, Hofbauer et al.[1] conduct a genome-wide screen in Drosophila melanogaster and reveal three silencer types that appear to work alone-without the need for combinatorial action, traditional chromatin marks, or open chromatin regions.