Hawes, J.J., Ashe, A. (2025). Moving epigenetic inheritance into the space age: Evidence that 3D genome organization is required for the establishment of epigenetic memory.  Mol. Cell 85(4): 667--669.

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Note

In this issue, Fitz-James et al.[1] use genetic manipulations to show that transient interchromosomal contacts between distant regulatory elements, mediated by the transcription factor GAF, can initiate transgenerational epigenetic inheritance in D. melanogaster.