Abstract
In a recent study, Thakur and O'Connor-Giles identified PDZD8 as a novel regulator of activity-dependent synaptic growth in Drosophila. Localized at endoplasmic reticulum (ER)-late endosome/lysosome (LEL) membrane contact sites (MCSs), PDZD8 promotes autophagy by coupling lipid transfer to autolysosome maturation to drive synaptic bouton formation, providing in vivo evidence that autophagy contributes directly to synaptic remodeling.
