Hale, C.M., Beauchemin, K.J., Brann, C.L., Moulton, J.K., Geguchadze, R., Harrison, B.J., Ganter, G.K. (2025). RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury. Data (Basel) 10(2): 11.
FlyBase ID
FBrf0263235
Publication Type
Research paper
Abstract
To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drososophila larvae and those of uninjured larvae. Third-instar larvae expressing a green fluorescent protein (GFP)-tagged ribosomal subunit specifically in Class 4 dendritic arborization neurons, recognized as pickpocket-expressing primary nociceptors, via the GAL4/UAS method, were injured by ultraviolet light or sham-injured. Larvae were subjected to translating ribosome affinity purification for the GFP tag and nociceptor-specific ribosome-bound RNA was sequenced.
