FB2026_02 , released June 18, 2026
Reference Report
Open Close
Reference
Citation
Popodi, E.M., Parks, A.L., Rusch, D. (2025.8.28). Whole genome sequencing suggests l(3)CHb is Cmpk. 
FlyBase ID
FBrf0263318
Publication Type
Personal communication to FlyBase
Abstract
PubMed ID
PubMed Central ID
Text of Personal Communication 
l(3)CHb1 (FBal0195755) and l(3)CHb2 (FBal0195756) are alleles identified in a screen for lethals over Df(3R)Espl3 and Df(3R)Exel6204 by Stephen Crews.  l(3)CHb is group 4 in Jiang and Crews, 2006 (FBrf0193980, see also FBrf0199131). Further crosses by the Bloomington Drosophila Stock Center shows non-complementation of both l(3)CHb alleles with Df(3R)BSC751 (RRID:BDSC_26849) and Df(3R)ED6232 (RRID:BDSC_8105), placing l(3)CHb between  3R:26 ,036,876 and  3R:26 ,055,324. This region contains six genes: E(spl)m7-HLH, E(spl)m8-HLH, gro, Exo84, Vps2 and Cmpk.  Whole genome sequencing reveals the following candidate mutations in the Cmpk gene (no likely candidates were found in any of the other genes): 
l(3)CHb1 - Cmpk-PA P150S (CCA->TCA)
l(3)CHb2 - Cmpk-PA R185W (CGG->TGG)
Please note!  In the absence of available verified alleles for Cmpk, we have not genetically confirmed Cmpk as the causative gene.
DOI
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Abbreviation
    Title
    ISBN/ISSN
    Data From Reference
    Aberrations (2)
    Alleles (2)
    Genes (1)