Falcone, S., Weber, A., Awad, S., Rieder, L. (2026). The histone gene family in Drosophila simulans carries consistent species-specific nucleotide polymorphisms distinct from that of Drosophila melanogaster. MicroPubl Biol 2026(): .
FlyBase ID
FBrf0265504
Publication Type
Research paper
Abstract
Drosophila melanogaster is a powerful model system to study histone gene regulation. However, D. melanogaster histone coding sequences are nearly identical, constraining use of this model in elucidating the regulation of individual members of this gene family. While we found similar constraints in D. simulans, we confirmed species-specific SNPs between D. simulans and D. melanogaster histone coding sequences and discovered these SNPs are consistent across D. simulans histone gene paralogs. We suggest that the SNPs between species-and the ability for D. melanogaster and D. simulans to hybridize-open new avenues to explore evolutionary conservation of histone gene regulation between similar species.
