Flanagan, T., Caterina, M., Muteba, T., Moulton, J., Ganter, G. (2026). Arrow promotes nociceptive sensitivity in Drosophila melanogaster. Mol. Pain 22(): 17448069261453747.
FlyBase ID
FBrf0265669
Publication Type
Research paper
Abstract
Normal sensitivity of the Drosophila larval nociceptor requires the activity of the Wg/WNT signaling pathway. When the nociceptor expression of Wg/WNT co-receptor Arrow, Drosophila ortholog of LRP5/6, is impaired by RNA interference, the larva becomes significantly hyposensitive to noxious thermal and mechanical stimulation. The reduced sensitivity was not associated with significant changes in dendritic architecture.
