Abstract
Bosveld et al. uncover how epithelial tissue buffers mitotic spindle errors. In the Drosophila notum, cells displaced by spindle misorientation either reintegrate via cell-autonomous and nonautonomous forces or are eliminated. This coordinated response links cell and tissue mechanics, Hippo-dependent survival signaling, and systemic tumor necrosis factor signaling-mediated apoptosis to maintain epithelial homeostasis.
