Pleckstrin homology domain of the Mus musculus thymoma viral proto-oncogene 1 (Akt1) gene (MGI:MGI:87986). This domain binds specifically to phosphatidylinositol 3,4,5-trisphosphate. This domain can thus be used to monitor the distribution of phosphatidylinositol 3,4,5-trisphosphate within a cell, if fused to an appropriate reporter protein (FBrf0224982), or to target a tagged protein to a particular subcellular localization via phosphatidylinositol 3,4,5-trisphosphate binding.