FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: P{UAS-αACT.Q70}
Open Close
General Information
Symbol
P{UAS-αACT.Q70}
FlyBase ID
FBtp0112730
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\CACNA1AUAS.αACT.Q70
Also Known As
α1ACT(Q70)
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\CACNA1AUAS.αACT.Q70
Transgenic product class
trinucleotide_repeat_expansion
(Tsou et al., 2015)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\CACNA1A
Description

UAS drives expression of the entire mRNA sequence of the transcription factor "α1ACT" (with its native start and stop codons), which is one product of the bicistronic Hsap\CACNA1A gene. The CAG repeat/polyQ region that is linked to spinocerebellar ataxia type 6 occurs within α1ACT, and this construct contains a pathogenic, polyQ-expanded version with a repeat of 70Q. (The wild type CAG repeat is between 4 and 18, whereas the SCA6-causing allele shows an expansion between 19 and 33 repeats.)

(Tsou et al., 2015)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
P{UAS-αACT.Q70}
(FlyBase, 1992-)
UAS-α1ACTQ70
(Sujkowski et al., 2022)
pWALIUM-UAS-α1ACT-70Q
(Tsou et al., 2016)
α1ACT(Q70)
(Johnson et al., 2021, Tsou et al., 2015)
Secondary FlyBase IDs
    References (6)