FB2026_03 , released September 17, 2026
Recombinant Construct: PBac{amx-hTM2D3.P155L}
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General Information
Symbol
PBac{amx-hTM2D3.P155L}
FlyBase ID
FBtp0126923
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\TM2D3P155L.amx
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\TM2D3P155L.amx
Transgenic product class
missense_variant
(Jakobsdottir et al., 2016)
Component
Use(s)
Regulatory region(s)
amx
Encoded product / tool
Hsap\TM2D3
Description

Genomic fragment (coordinates X:9245044..9248369 , release 6 genome) encompassing the amx transcription unit in which the amx coding region has been replaced by the Hsap\TM2D3 variant 1 coding sequence (derived from cDNA clone NM_078474), allowing expression of the human gene under the control of amx regulatory sequences. In addition, the Hsap\TM2D3 coding sequence has been mutated to carry the P155L variant that is associated with increased risk and earlier onset of late-onset Alzheimer's disease.

(Jakobsdottir et al., 2016)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
PBac{amx-hTM2D3.P155L}
(FlyBase, 1992-)
TM2D3[P155L]
(Jakobsdottir et al., 2016)
Secondary FlyBase IDs
    References (3)