FB2026_02 , released June 18, 2026
Recombinant Construct: P{UAS-BCR::ABL1.p210.T315I}
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General Information
Symbol
P{UAS-BCR::ABL1.p210.T315I}
FlyBase ID
FBtp0141455
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\ABL1::Hsap\BCRT315I.UAS.p210
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\ABL1::Hsap\BCRT315I.UAS.p210
Transgenic product class
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ABL1::Hsap\BCR
Description

UASt regulatory sequences drive expression of a Hsap\ABL1::Hsap\BCR fusion gene that produces a p210 kDa protein. This particular gene fusion accounts for over 95% of chronic myeloid leukemia patients. In addition, the protein carries a T to I amino acid replacement at position 315 in the Hsap\ABL1 kinase domain, a point mutation that results in resistance of tumors to many tyrosine kinase inhibitors.

(Outa et al., 2020)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
P{UAS-BCR::ABL1.p210.T315I}
(FlyBase, 1992-)
UAS-BCR-ABLT315I
(Abubaker et al., 2022)
Secondary FlyBase IDs
    References (4)