FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: P{Orc6-UAS-Orc6.N-GFP.K23E}
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General Information
Symbol
P{Orc6-UAS-Orc6.N-GFP.K23E}
FlyBase ID
FBtp0145887
Feature type
transgenic_transposable_element
Component Allele(s)
Orc6K23E.Orc6.UAS.GFP
Size
Expression Data
Associated insertion(s)
4 available
Molecular map
Description and Uses
Construct components
Component allele Orc6K23E.Orc6.UAS.GFP
Transgenic product class
missense_variant
(Balasov et al., 2020)
Component
Use(s)
Regulatory region(s)
Orc6
UASt
Encoded product / tool
Orc6
Tagged with
GFP
Description

The native Orc6 promoter and UASt regulatory sequences are fused upstream of a mutated form of Orc6 that contains a K23E amino acid substitution. This change is equivalent to a K23E change in the orthologous human ORC6 gene, a variant identified in a patient with Meier-Gorlin syndrome. The coding sequence is tagged at the N-terminal end with GFP.

(Balasov et al., 2020)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
GFP-Orc6-DmK23E
(Balasov et al., 2020)
P{Orc6-UAS-Orc6.N-GFP.K23E}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)