FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: M{UAS-Fmr1.KH1KH2mut.EGFP}
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General Information
Symbol
M{UAS-Fmr1.KH1KH2mut.EGFP}
FlyBase ID
FBtp0150154
Feature type
transgenic_transposable_element
Component Allele(s)
Fmr1KH1KH2mut.UAS.EGFP
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Construct components
Component allele Fmr1KH1KH2mut.UAS.EGFP
Transgenic product class
missense_variant
(Starke et al., 2022)
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fmr1
Tagged with
EGFP
Description

UASt regulatory sequences drive expression of the Fmr1 coding region (amplified from the LD09557 cDNA), carrying both a G269E substitution in the KH1 domain and a I307N substitution in the KH2 domain. These changes are equivalent to a G266E change and a I304N change respectively in the orthologous human FMR1 gene (each of these variants is associated with Fragile X Syndrome). The coding sequence is tagged at the N-terminal end with EGFP.

(Starke et al., 2022)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
EGFP:FMRP:KH1*KH2*
(Starke et al., 2022)
M{UAS-Fmr1.KH1KH2mut.EGFP}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)