FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 3'-5'-RNA exonuclease activity ID (Ontology) GO:0000175 (Gene Ontology)
Definition Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.[ ISBN:0198547684 ]
Also Known As "3'-5' exoribonuclease activity" ; "3'-5'-exoribonuclease activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3'-5'-RNA exonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3'-5'-RNA exonuclease activity       --
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exonuclease activity
 |__3'-5' exonuclease activity________________________________
RNA exonuclease activity                                      |
 |__RNA exonuclease activity, producing 5'-phosphomonoesters__|
                                                              3'-5'-RNA exonuclease activity  21 rec.
                                                               |__3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
                                                               |__exoribonuclease II activity
                                                               |__poly(A)-specific ribonuclease activity 6 rec.
                                                               |__poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends 1 rec.
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Is a 3'-5' exonuclease activity
RNA exonuclease activity, producing 5'-phosphomonoesters
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Synonyms
  • "3'-5' exoribonuclease activity" EXACT
    "3'-5'-exoribonuclease activity" EXACT
Secondary IDs
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Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion"
Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA"
Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA"
Reactome:R-HSA-9694632 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA"
Reactome:R-HSA-9822437 "DIS3L2 hydrolyzes uridylated mRNA"
Reactome:R-HSA-9836585 "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides"
Reactome:R-HSA-9836822 "REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides"
Reactome:R-HSA-9933585 "RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA"
Reactome:R-HSA-9934763 "The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA"
Reactome:R-HSA-9935824 "TRAMP:RNA exosome hydrolyzes oligoadenylated pre-rRNA 5' external transcribed spacer (5'ETS)"