FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term nuclear exosome (RNase complex) ID (Ontology) GO:0000176 (Gene Ontology)
Definition A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.[ PubMed:17174896 PubMed:20531386 PubMed:26726035 ]
Also Known As"eukaryotic exosome multienzyme ribonuclease complex" ; "nuclear exosome (ribonuclease complex)" ; "nuclear exosome multienzyme ribonuclease complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 nuclear exosome (RNase complex) (all annotations which use CV term, excluding "NOT" statements)
     part_of | nuclear exosome (RNase complex)       --
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intracellular anatomical structure
 |__exosome (RNase complex)_____________
nucleus                                 |
 |__nuclear lumen_______________________|
 |__nuclear protein-containing complex__|
protein-containing complex              |
 |__nuclear protein-containing complex__|
intracellular organelle lumen           |
 |__nuclear lumen_______________________|
exoribonuclease complex                 |
 |__exosome (RNase complex)_____________|
                                        nuclear exosome (RNase complex)  11 rec.
                                         |__nucleolar exosome (RNase complex)
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Is a exosome (RNase complex)
nuclear protein-containing complex
Part of nuclear lumen
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Synonyms
  • "eukaryotic exosome multienzyme ribonuclease complex" EXACT
    "nuclear exosome (ribonuclease complex)" EXACT
    "nuclear exosome multienzyme ribonuclease complex" EXACT
Secondary IDs
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