FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

rRNA (adenine-N6,N6-)-dimethyltransferase activity

ID (Ontology)

GO:0000179 (Gene Ontology)

Definition

Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.[ ISBN:1555811337 PubMed:10690410 ]

Also Known As

"18S rRNA dimethylase activity" ; "dimethyladenosine transferase activity" ; "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
rRNA (adenine-N6,N6-)-dimethyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| rRNA (adenine-N6,N6-)-dimethyltransferase activity

Spanning Tree (Parents/Children)

methyltransferase activity
 |__N-methyltransferase activity_______________
rRNA methyltransferase activity                |
 |__rRNA (adenine) methyltransferase activity__|
                                               rRNA (adenine-N6,N6-)-dimethyltransferase activity  3 rec.
                                                |__16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
                                                |__18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	N-methyltransferase activity rRNA (adenine) methyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"18S rRNA dimethylase activity" EXACT "dimethyladenosine transferase activity" EXACT "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851" Reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937"