FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ID (Ontology) GO:0000184 (Gene Ontology)
Definition The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.[ PubMed:10025395 ]
Also Known As "mRNA breakdown, nonsense-mediated decay" ; "mRNA catabolic process, nonsense-mediated" ; "mRNA catabolism, nonsense-mediated" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      16
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Relevant FlyBase reports
 Genes
 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (all annotations which use CV term, excluding "NOT" statements)      16
     involved_in | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay      16
 NOT | involved_in | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay       4
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  mRNA catabolic process
   |__nuclear-transcribed mRNA catabolic process
       |__nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  18 rec.
           |__nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay 2 rec.
           |__nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
           |__regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1 rec.
               |__negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
               |__positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1 rec.
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Is a nuclear-transcribed mRNA catabolic process
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Synonyms
  • "mRNA breakdown, nonsense-mediated decay" EXACT
    "mRNA catabolic process, nonsense-mediated" EXACT
    "mRNA catabolism, nonsense-mediated" EXACT
    "mRNA degradation, nonsense-mediated decay" EXACT
    "nonsense-mediated mRNA decay" EXACT
    "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-927802 "Nonsense-Mediated Decay (NMD)"
Wikipedia:Nonsense-mediated_decay
Wikipedia:Nonsense-mediated_mRNA_decay