FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ID (Ontology) GO:0000224 (Gene Ontology)
Definition Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.[ EC:3 ]
Also Known As "PNGase"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity       1
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  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
   |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
       |__peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity  1 rec.
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Is a hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
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Synonyms
  • "glycopeptidase activity" BROAD[ EC:3 ]
    "glycopeptide N-glycosidase activity" BROAD[ EC:3 ]
    "jack-bean glycopeptidase" NARROW[ EC:3 ]
    "N-glycanase activity" RELATED[ EC:3 ]
    "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED[ EC:3 ]
    "N-oligosaccharide glycopeptidase activity" RELATED[ EC:3 ]
    "peptide:N-glycanase" RELATED
    "PNGase" EXACT
    "PNGase A" RELATED[ EC:3 ]
    "PNGase F" RELATED[ EC:3 ]
Secondary IDs
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EC:3.5.1.52
MetaCyc:3.5.1.52-RXN
Reactome:R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins"