FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term N-acetylglucosaminylphosphatidylinositol deacetylase activity ID (Ontology) GO:0000225 (Gene Ontology)
Definition Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane.[ EC:3 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 N-acetylglucosaminylphosphatidylinositol deacetylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | N-acetylglucosaminylphosphatidylinositol deacetylase activity
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides__
deacylase activity                                                                           |
 |__deacetylase activity_____________________________________________________________________|
                                                                                         N-acetylglucosaminylphosphatidylinositol deacetylase activity  1 rec.
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Is a hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
deacetylase activity
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Synonyms
  • "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" RELATED[ EC:3 ]
    "acetylglucosaminylphosphatidylinositol deacetylase activity" RELATED[ EC:3 ]
    "GlcNAc-PI de-N-acetylase activity" RELATED[ EC:3 ]
    "GlcNAc-PI deacetylase activity" RELATED[ EC:3 ]
    "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" RELATED[ EC:3 ]
    "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.5.1.89
MetaCyc:3.1.1.69-RXN
Reactome:R-HSA-162857 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate"
RHEA:11660