FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity ID (Ontology) GO:0000253 (Gene Ontology)
Definition Catalysis of the reaction: a 3-betahydroxyl sterol + NADP+ = a 3-oxosterol sterol + NADPH + H+.[ EC:1 PubMed:9811880 ]
Also Known As "3-keto sterol reductase activity" ; "3-keto-steroid reductase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       8
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 Genes
 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)       8
     enables | 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity       8
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steroid dehydrogenase activity_________________________________________________________
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor__|
                                                                                       steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
                                                                                        |__3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity  8 rec.
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Is a steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "3-keto sterol reductase activity" EXACT
    "3-keto-steroid reductase activity" EXACT
    "3-KSR activity" RELATED[ EC:1 ]
    "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.270
MetaCyc:RXN-13686
Reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)"
Reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol"
Reactome:R-HSA-9945784 "HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol"
Reactome:R-HSA-9945804 "HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL"
RHEA:18409
RHEA:33459
RHEA:34787
RHEA:36379
RHEA:46216
RHEA:46832
RHEA:46852
RHEA:56880
RHEA:56916
RHEA:69012
RHEA:69036
RHEA:85555
RHEA:85563