FB2026_03 , released September 17, 2026
CV Term Report
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Term C-4 methylsterol oxidase activity ID (Ontology) GO:0000254 (Gene Ontology)
Definition Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.
Also Known As"4-methylsterol oxidase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 C-4 methylsterol oxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | C-4 methylsterol oxidase activity
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
                                                                                          |__C-4 methylsterol oxidase activity  2 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "4-methylsterol oxidase activity" EXACT[ EC:1 ]
    "methylsterol hydroxylase activity" RELATED[ EC:1 ]
    "methylsterol monooxygenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.18.9
MetaCyc:RXN-13188
Reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol"
Reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol"
Reactome:R-HSA-9947203 "MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol"
Reactome:R-HSA-9947207 "MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol"
RHEA:55220