FB2026_03 , released September 17, 2026
CV Term Report
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Term nucleoplasmic THO complex ID (Ontology) GO:0000446 (Gene Ontology)
Definition The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.[ PubMed:11060033 PubMed:11979277 PubMed:16983072 ]
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 nucleoplasmic THO complex (all annotations which use CV term, excluding "NOT" statements)
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nucleoplasm
 |__transcription elongation factor complex__
nuclear protein-containing complex           |
 |__THO complex______________________________|
 |__transcription elongation factor complex__|
                                             nucleoplasmic THO complex  1 rec.
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