FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity ID (Ontology) GO:0000703 (Gene Ontology)
Definition Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.[ PubMed:11554296 ]
Also Known As "oxidized pyrimidine base lesion DNA N-glycosylase activity"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity       2
Spanning Tree (Parents/Children)
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  DNA N-glycosylase activity
   |__oxidized base lesion DNA N-glycosylase activity
       |__oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity  2 rec.
           |__5-formyluracil DNA N-glycosylase activity
           |__5-hydroxymethyluracil DNA N-glycosylase activity
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Is a oxidized base lesion DNA N-glycosylase activity
Part of
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Synonyms
  • "bifunctional DNA glycosylase" BROAD
    "DNA glycosylase/AP-lyase" BROAD
    "DNA glycosylase/beta-lyase" BROAD
    "endodeoxyribonuclease III" RELATED
    "endonuclease III" RELATED
    "endonuclease VIII activity" RELATED
    "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT
    "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED
Secondary IDs
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Reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase"
Reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase"
Reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase"