FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

ID (Ontology)

GO:0000703 (Gene Ontology)

Definition

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.[ PubMed:11554296 ]

Also Known As

"oxidized pyrimidine base lesion DNA N-glycosylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Spanning Tree (Parents/Children)

  DNA N-glycosylase activity
   |__oxidized base lesion DNA N-glycosylase activity
       |__oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity  1 rec.
           |__5-formyluracil DNA N-glycosylase activity
           |__5-hydroxymethyluracil DNA N-glycosylase activity

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	oxidized base lesion DNA N-glycosylase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"bifunctional DNA glycosylase" BROAD "DNA glycosylase/AP-lyase" BROAD "DNA glycosylase/beta-lyase" BROAD "endodeoxyribonuclease III" RELATED "endonuclease III" RELATED "endonuclease VIII activity" RELATED "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase" Reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase" Reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase"