FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

Prp19 complex

ID (Ontology)

GO:0000974 (Gene Ontology)

Definition

A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.[ PubMed:16540691 PubMed:19239890 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
Prp19 complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| Prp19 complex

Spanning Tree (Parents/Children)

  cellular_component
   |__protein-containing complex
       |__Prp19 complex  13 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein-containing complex
Part of
Synonyms & Secondary IDs
Synonyms
	"MOS4-Associated Complex" NARROW[ PubMed:28947490 ] "nineteen complex" NARROW "NTC" RELATED "Prp19/CDC5 complex" NARROW
Secondary IDs

External Crossreferences & Linkouts