FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term fatty acid alpha-oxidation ID (Ontology) GO:0001561 (Gene Ontology)
Definition A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.[ PubMed:10198260 ]
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 fatty acid alpha-oxidation (all annotations which use CV term, excluding "NOT" statements)
     involved_in | fatty acid alpha-oxidation
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fatty acid metabolic process
 |__fatty acid catabolic process_______
 |__fatty acid oxidation_______________|
lipid catabolic process                |
 |__fatty acid catabolic process_______|
lipid oxidation                        |
 |__fatty acid oxidation_______________|
monocarboxylic acid catabolic process  |
 |__fatty acid catabolic process_______|
                                       fatty acid alpha-oxidation  2 rec.
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Is a fatty acid catabolic process
fatty acid oxidation
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MetaCyc:PWY-2501
MetaCyc:PWY66-387
Reactome:R-HSA-389599 "Alpha-oxidation of phytanate"