FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ID (Ontology) GO:0001888 (Gene Ontology)
Definition Catalysis of the reaction: 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP.[ EC:2 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
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UDP-glycosyltransferase activity__
hexosyltransferase activity_______|
                                  acetylglucosaminyltransferase activity
                                   |__glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity  1 rec.
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Is a acetylglucosaminyltransferase activity
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Synonyms
  • "alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED[ EC:2 ]
    "alpha-N-acetylglucosaminyltransferase I activity" RELATED[ EC:2 ]
    "alpha1,4-N-acetylglucosaminyltransferase activity" RELATED[ EC:2 ]
    "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.1.223
MetaCyc:2.4.1.223-RXN
Reactome:R-HSA-9953259 "EXTL3 dimer transfers GlcNAc to the GAG linker"
RHEA:16221