FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

desensitization of G protein-coupled receptor signaling pathway

ID (Ontology)

GO:0002029 (Gene Ontology)

Definition

The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.[ PubMed:8396717 ]

Also Known As

"desensitisation of G-protein coupled receptor protein signalling pathway" ; "desensitization of G-protein coupled receptor protein signaling pathway"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
desensitization of G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| desensitization of G protein-coupled receptor signaling pathway

Spanning Tree (Parents/Children)

regulation of G protein-coupled receptor signaling pathway
 |__negative regulation of G protein-coupled receptor signaling pathway__
negative regulation of signal transduction                               |
 |__negative adaptation of signaling pathway_____________________________|
 |__negative regulation of G protein-coupled receptor signaling pathway__|
adaptation of signaling pathway                                          |
 |__negative adaptation of signaling pathway_____________________________|
                                                                         desensitization of G protein-coupled receptor signaling pathway  4 rec.
                                                                          |__G protein-coupled receptor internalization 4 rec.
                                                                          |   |__prostaglandin receptor internalization
                                                                          |   |__regulation of G protein-coupled receptor internalization(+)
                                                                          |__inhibitory G protein-coupled receptor phosphorylation
                                                                              |__regulation of inhibitory G protein-coupled receptor phosphorylation(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	negative adaptation of signaling pathway negative regulation of G protein-coupled receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"desensitisation of G-protein coupled receptor protein signalling pathway" EXACT "desensitization of G-protein coupled receptor protein signaling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts