FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term protein disulfide isomerase activity ID (Ontology) GO:0003756 (Gene Ontology)
Definition Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.[ EC:5 ]
Also Known As "disulphide bond formation" ; "protein disulfide-isomerase" ; "protein disulphide isomerase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein disulfide isomerase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein disulfide isomerase activity       --
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catalytic activity
 |__catalytic activity, acting on a protein________________________
intramolecular oxidoreductase activity                             |
 |__intramolecular oxidoreductase activity, transposing S-S bonds__|
                                                                   protein disulfide isomerase activity  13 rec.
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Is a intramolecular oxidoreductase activity, transposing S-S bonds
catalytic activity, acting on a protein
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Synonyms
  • "disulphide bond formation" EXACT
    "protein cysteine-thiol oxidation" RELATED
    "protein disulfide-isomerase" EXACT[ EC:5 ]
    "protein disulphide isomerase activity" EXACT
    "protein thiol-disulfide exchange" EXACT
    "protein thiol-disulphide exchange" EXACT
    "S-S rearrangase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.3.4.1
MetaCyc:5.3.4.1-RXN
Reactome:R-HSA-8950113 "IL12A binds IL12B"
Reactome:R-HSA-8950183 "IL12B binds IL23A"
Reactome:R-HSA-8950456 "IL12B dimerizes"
Reactome:R-HSA-9760559 "DsbA catalyzes disulfide crosslink formation on STa"