FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein-glutamine gamma-glutamyltransferase activity ID (Ontology) GO:0003810 (Gene Ontology)
Definition Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.[ EC:2 ]
Also Known As"fibrinoligase activity" ; "TGase activity" ; "transglutaminase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein-glutamine gamma-glutamyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein-glutamine gamma-glutamyltransferase activity
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catalytic activity
 |__catalytic activity, acting on a protein__
acyltransferase activity                     |
 |__aminoacyltransferase activity____________|
                                             protein-glutamine gamma-glutamyltransferase activity  1 rec.
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Is a aminoacyltransferase activity
catalytic activity, acting on a protein
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Synonyms
  • "factor XIIIa" RELATED[ EC:2 ]
    "fibrin stabilizing factor" RELATED[ EC:2 ]
    "fibrinoligase activity" EXACT
    "glutaminylpeptide gamma-glutamyltransferase activity" RELATED[ EC:2 ]
    "polyamine transglutaminase activity" RELATED[ EC:2 ]
    "protein-glutamine:amine gamma-glutamyltransferase" RELATED[ EC:2 ]
    "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" RELATED[ EC:2 ]
    "TGase activity" EXACT
    "tissue transglutaminase" NARROW[ EC:2 ]
    "transglutaminase activity" EXACT
Secondary IDs
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EC:2.3.2.13
MetaCyc:2.3.2.13-RXN
Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+"
Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking"
RHEA:54816