FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term gamma-glutamylcyclotransferase activity ID (Ontology) GO:0003839 (Gene Ontology)
Definition Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.[ PubMed:18515354 ]
Also Known As "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" ; "gamma-glutamyl-amino acid cyclotransferase activity" ; "gamma-L-glutamylcyclotransferase activity" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 gamma-glutamylcyclotransferase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | gamma-glutamylcyclotransferase activity       2
Spanning Tree (Parents/Children)
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  carbon-nitrogen lyase activity
   |__amidine-lyase activity
       |__gamma-glutamylcyclotransferase activity  2 rec.
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Is a amidine-lyase activity
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Synonyms
  • "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT
    "gamma-glutamyl-amino acid cyclotransferase activity" EXACT
    "gamma-L-glutamylcyclotransferase activity" EXACT
    "L-glutamic cyclase activity" EXACT
Secondary IDs
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EC:4.3.2.9
MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO"
Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly"
RHEA:20505