FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity ID (Ontology) GO:0003842 (Gene Ontology)
Definition L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + 2 H+.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity       --
 NOT | enables | L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity       --
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  aldehyde dehydrogenase [NAD(P)+] activity
   |__aldehyde dehydrogenase (NAD+) activity
       |__L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity  3 rec.
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Is a aldehyde dehydrogenase (NAD+) activity
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Synonyms
  • "1-pyrroline dehydrogenase" BROAD
    "1-pyrroline-5-carboxylate dehydrogenase activity" RELATED
    "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" RELATED
    "delta1-pyrroline-5-carboxylate dehydrogenase activity" RELATED[ EC:1 ]
    "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" RELATED
    "pyrroline-5-carboxylate dehydrogenase activity" RELATED[ EC:1 ]
    "pyrroline-5-carboxylic acid dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.2.1.88
MetaCyc:RXN-14116
Reactome:R-HSA-6784402 "ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate"
Reactome:R-HSA-70679 "ALDH4A1 oxidises L-GluSS to Glu"
Reactome:R-HSA-9929439 "ALDH4A1 oxidizes 1PYR-3OH-5COOH"
RHEA:30235